Manufacturing technologies

Explore our specialized sterile manufacturing technologies for late-phase and commercial drug product manufacture, from fill-finish and high-containment production, to lyophilization and water for injection.

Sterile manufacturing delivered at scale.

Every ROIS site combines dedicated technology with the quality systems and regulatory experience pharmaceutical and biotechnology partners rely on at every stage of their program.

14 aseptic filling lines across the network with flexible, cost efficient RABS technology and the latest isolator technology. Further capabilities at the US-based site include OEB5 cytotoxic manufacturing and lyophilization with four autoloading lyophilizers.

Proven expertise

Over 50 years of sterile manufacturing experience

Global capacity

Facilities across Europe and the US supporting commercial supply at scale

Regulatory credibility

Commercial approvals across more than 75 global markets

Personal partnerships

Direct access to the technical teams advancing your program

Choose a technology

Sterile manufacturing

Specialized sterile manufacturing technologies supporting late-phase and commercial drug product manufacture, from fill-finish of standard biologic and small molecule procucts, to the speciality handling required for high-containment production and lyophilization.

Cytotoxic filling and lyophilization

Segregated OEB5 cytotoxic manufacturing for oncology and ADC drug products, with dedicated US-based vial filling and four autoloading lyophilizers, backed by 50 years of manufacturing experience.

Explore further

Packaging and integrated services

End-to-end support spanning analytical studies, packaging, device assembly, storage and logistics; ROIS simplifies project complexity with end-to-end solutions.

Modalities

Manufacturing expertise from biologics and biosimilars to vaccines, ADCs, and emerging modalities.

Locations

Five manufacturing sites across Spain and the US give your program a consistent route from development through commercial supply.

News and resources

Explore expert insights, technical perspectives, and industry trends shaping the future of injectable manufacturing.

News and resources

ROIS: The CDMO making waves in the US market

ROIS Phoenix Facility

ROIS CDMO closes on the acquisition of US injectable manufacturing facility

Water for injection: why WFI is now a strategic manufacturing decision

Our locations

Phoenix

ROIS Phoenix is a commercial-scale sterile manufacturing facility specializing in cytotoxic and ADC fill-finish for late-phase and commercial programs.

Madrid

ROIS Julian Camarillo is a commercial-scale sterile injectable manufacturing facility specializing in prefilled syringe fill-finish for investigational and commercial products.

San Sebastián de los Reyes

Specializing in commercial-scale sterile manufacturing of aseptic fill-finish of small-volume injectable products across vials, prefilled syringes, and cartridges.

Alcalá de Henares

ROIS Alcala de Henares is a commercial-scale pharmaceutical manufacturing campus specializing in oral solid dose manufacturing, injectable packaging, and drug-device assembly.

Granada

ROIS Granada is a Drug Substance Center of Excellence specializing in complex API development, mRNA technologies, and lipid nanoparticle (LNP) formulation.

Personalized partnerships. Global reach.

Connect with the ROIS team to explore how we can support your next program.